Current Issue : July-September Volume : 2021 Issue Number : 3 Articles : 4 Articles
Paroxetine (PAX) is a powerful and selective serotonin reuptake inhibitor (SSRI) with some neuropharmacological properties used mainly for the treatment of anxiety and depression. Due to the first pass degradation, PAX suffers poor bioavailability issues and this limits its clinical application. In context to this, the present review focuses the various formulations related with transdermal liposomes, nano emulsion via olfactory region and brain targeted intranasal in-situ gelling spray for the management of depression. Additionally, we also discuss about the various analytical methods such as HPLC, HPTLC, UV, LC-MS/MS, GC-MS which are reliable and sensitive for the quantification of PAX in different pharmaceutical dosage forms. This concise review presents the survey of physiochemical properties, transdermal as well as intranasal drug delivery systems and analytical methods used for PAX determination, being carried out through scientific journals as well as official compendia....
Itraconazole (ITZ) is an antifungal triazole, used to treat systemic and superficial fungal infections. Its clinical effectiveness is limited due to its low water solubility which results in poor bioavailability. Therefore, there is a need to develop a trailblazer formulation capable to enhance solubility, dissolution and bioabsorption of ITZ for better topical and systemic use. In context to this, this review represents the summary of physicochemical characteristics, various nano dosage forms and analytical methods utilized for ITZ. The quantifications of ITZ have already been published in various kind of literature with a special focus on UV-Vis spectrophotometric, spectrofluorometric, HPLC and other hyphenated techniques. Numerous parameters like λmax, solvents, stationary phase, mobile phase, retention time, column have been demonstrated. This concise report reveals all the analytical methods already used with its important parameters for the estimation of ITZ that will benefit researchers and contribute to the existence in this area....
Chemometric assisted UV spectrophotometric method and RP-HPLC was developed for simultaneous estimation of metoprolol succinate (METO) and Olmesartanmedoxomil (OLME) in their combined dosage form. Multivariate calibration methods (Classical Least Squares and Inverse Least Squares) using the absorption spectra in the region of 220-300 nm were proposed for the resolution of strongly overlapping spectra of metoprolol succinate (METO) and olmesartan medoxomil (OLME) in binary mixtures. In RP-HPLC, the method was developed using Phenomenex Luna C18 column (150 X 4.6 mm i.d., 5μm), with mobile phase composition of acetonitrile:phosphate buffer, pH 3.0 (45:55, v/v). The flow rate was 0.7 mL/min and effluent was monitored at 224 nm. The retention time of METO and OLME were 2.408 min and 6.167 min, respectively. Linearity was observed over the concentration range of 5-30 μg/ml for both the drugs. The developed method was validated as per ICH guidelines. The proposed methods were successfully applied for the quantification of METO and OLME in pharmaceutical formulations....
Amlodipine besylate is an anti-hypertensive drug belong to the category calcium channels blocker. It is commonly used in treatment of hypertension and angina. Amlodipine besylate is pharmacologically very effective, but due to photosensitive nature it undergoes an easy degradation which affects on bioavailability of drug. The objective of present study was to stabilize amlodipine besylate from degradation by polymorphic modification. The system of amlodipine besylate was prepared by applying magnetic field with magnet of power 10000 Tesla for 1 h and by using methanol as solvent for crystallization. The prepared crystals were evaluated for degradation of amlodipine besylate up to 30 days by using titrimetric methodology, solubility, melting point and characterization by using X-ray diffraction pattern and differential scanning colorimetry. This attributes to the changes occurred in an arrangement of atoms during alignment at various environment. Consequently inter atomic and inter planner distance changes associated with crystallization results in enhanced resistance against the all sources of degradants. Some conformational changes occurred with the change of environment for crystallization of amlodipine besylate and the polymorphic changes are the reason of stabilization of amlodipine besylate from degradation....
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